As a main regulator of melanocyte development and an key melanoma oncogene, microphthalmia-associated transcription factor (MITF) is one of the proteins in the basic helix-loop-helix zipper (bHLHZip) transcription factor family.The study on the detailed binding specificity of the MITF/DNA complex has been a challenge.MITF-DNA interaction details an
In this study, an adaptive nonsingular terminal sliding mode control technique according to the barrier function is designed for the performance improvement and robust stability of nonlinear systems with outdoor disturbances.For this reason, a novel nonlinear sliding surface is presented based on the states of the system.The nonlinear sliding surfa
Abstract Background Fraud, Waste, and Abuse (FWA) in medical claims have a negative impact on the quality and cost of healthcare.A major component of FWA in claims is procedure code overutilization, where one or more prescribed procedures may not be relevant to a given diagnosis and patient profile, resulting in unnecessary and unwarranted treatmen
Within traditional design processes, decisions are often made based on individualistic values and late-stage assessments conducted on a predefined set of design alternatives potentially leading to suboptimal design decisions and conflicts.The issues are further amplified by the growing complexity of construction project management where an increasi
Rivers of the Arctic will become ever more important for the global climate, since they carry a invertatop squeeze bottle majority of continental dissolved organic carbon flux into the rapidly changing polar ocean.Aqueous organics comprise a wide array of functional groups, several of which are likely to impact coastal and open water biophysical pr